Estradiol is Estrogen

It is predominantly a hormone produced by the ovaries and the adrenal glands.  There are 3 types of estrogen that the body produces: Estradiol (most abundant during reproductive years), estrone (most prominent in menopause), and estriol (a weak estrogen that may have anti-cancer benefits).

Contrary to its reputation, estradiol is needed in men (for fat loss, longer lasting erection, bone health).

There are 3 main types:

Estrone: made in peripheral tissues, implicated in some cancers (breast, uterine)

Estradiol: made in ovaries; higher levels associated with youthful appearance; deficiencies associated with osteoporosis, dementia, heart disease

Estriol: safest and weakest; good for vaginal dryness and MS; may have anti-cancer benefits


Signs of low estrogen:

  • Weight gain
  • Incontinence
  • Mood changes/depression
  • Insomnia
  • Low libido
  • Heart palpitations
  • Osteoporosis
  • Painful intercourse
  • “Brain fog”
  • Irritability
  • Fatigue
  • Hot flashes
  • Pain

Benefits of estrogen replacement:

  1. Helps menopausal symptoms
  2. Helps maintain bone density
  3. Helps with mental function
  4. May decrease Alzheimer’s risk and other related brain issues
  5. Supports cognitive function and mood (serotonin function)
  6. Anti-aging benefits for appearance: stronger hair, smoother skin, improved muscle tone

Topical is best (gel better than creams, or using a patch). This transdermal method avoids “first pass effect” (i.e. increase of inflammation, liver issues, etc) and coagulation (i.e. increase risk of blood clots) issues of oral use. Estradiol is always best to combine with progesterone, especially if a woman has intact uterus.